What is DSIP?
DSIP (delta sleep-inducing peptide) is a peptide of nine amino acids that was found in 1974 in the blood of rabbits put into deep sleep. Researchers thought it might trigger deep “delta” sleep, which gave it its name.
Its official drug name is emideltide. A lab-made version is sold online for sleep, stress and pain.
What does DSIP do?
Nobody is sure. Despite decades of research, no receptor for DSIP has been found, and scientists still don’t agree on what it does in the body.
Studies have linked it to sleep, stress hormones, pain and body temperature, but the findings haven’t been consistent.
What does the research on DSIP show?
Human research peaked in the 1980s and early 1990s with small studies, mostly in people with insomnia. Some found longer, less broken sleep; others found no clear benefit, and reviews concluded it was unlikely to be a useful insomnia treatment.
There are no modern, well-designed trials of DSIP for sleep or anything else.
DSIP side effects and risks
Its side effects in people aren’t well known because it hasn’t been studied in modern trials. Products sold online aren’t checked for purity, strength or sterility.
Is DSIP legal?
DSIP is not approved for human use by the FDA or any other regulator. Its nomination was withdrawn from the FDA’s list of compounding substances with safety concerns, and in July 2026 an FDA advisory committee voted against adding it to the list pharmacies can use.
How do you reconstitute DSIP?
DSIP research vials hold a freeze-dried powder that is mixed with bacteriostatic water. The calculator above turns the vial size, the water and a dose into syringe units, and the reconstitution guide explains each step.
See the dosage section below for what is known about doses, with sources.