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What is epitalon (epithalon)?

Epitalon explained in plain English: what it is, what the research shows, side effects, legal status and dosage, plus a calculator for syringe units. There is no validated human dose, and this page doesn't invent one. Also called Epithalon, Epithalone, AEDG peptide.

Epitalon is not approved for human use by the FDA or any other regulator. This page is educational; talk with a qualified healthcare professional before using any substance.

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Vial unit

= 10,000 mcg

mL
Dose unit
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–units

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Syringe, no result yetU-100, 1 mL syringe holding up to 100 units. Enter your dose.0102030405060708090100

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What is epitalon?

Epitalon, also spelled epithalon, is a lab-made peptide of just four amino acids: alanine, glutamic acid, aspartic acid and glycine (AEDG). It was developed in Russia by Vladimir Khavinson’s aging research group.

It was designed to copy epithalamin, an extract from the pineal gland, the small brain gland that makes melatonin. It is sold online as a research peptide for longevity.

What is epitalon used for?

Epitalon is promoted as an anti-aging peptide that lengthens telomeres, the protective caps on the ends of chromosomes that shorten as cells age. People also use it hoping for better sleep, since it is linked to the pineal gland and melatonin.

None of these uses has been proven in rigorous human trials.

What does the research on epitalon show?

In cultured human cells, epitalon switched on telomerase, the enzyme that rebuilds telomeres, and let cells divide more times than untreated cells. Independent labs reported similar cell results in 2025.

Animal studies, mostly from the same Russian group, reported longer lifespans in mice and rats. There are no large, placebo-controlled human trials showing epitalon lengthens telomeres, slows aging or extends life.

Epitalon side effects and risks

Its side effects in people are largely unknown, because it hasn’t been properly tested. The FDA has noted a possible risk of immune reactions.

Switching on telomerase is also something cancer cells do, so researchers have raised the question of whether long-term use could affect cancer risk; nobody knows. Products sold online aren’t checked for purity or strength.

Epitalon is not approved for human use by the FDA or any other regulator. Its nomination was withdrawn from the FDA’s list of compounding substances with safety concerns, and in July 2026 an FDA advisory committee recommended allowing it in pharmacy compounding.

Neither step is an approval, and the FDA still has to decide.

How do you reconstitute epitalon?

Epitalon comes as a powder that is mixed with bacteriostatic water. The calculator above turns the vial size, the water and a dose into syringe units, and the reconstitution guide explains each step.

See the dosage section below for what is known about doses, with sources.

Epitalon dosage

Epitalon has no approved dose and no large human trials, so there is no validated human dose.

There is no approved or validated human dose. This site does not repeat doses from forums, sellers or animal studies.

Medical disclaimer: this dosage information is for education only and comes from the source shown for each row. It is not medical advice and not a recommendation for you. Only a licensed prescriber who knows your health can decide whether Epitalon is right for you and at what dose. Don't start, change or stop a medicine based on this page, and don't use research peptides or unapproved drugs based on trial doses.

Epitalon concentration chart

The concentration of a Epitalon vial depends only on its size and the water you add. Each unit on a U-100 syringe holds one hundredth of a mL.

Epitalon concentration by vial size and water
Vial + waterConcentrationPer unit (U-100)
10 mg + 1 mL10,000 mcg/mL (10 mg/mL)100 mcg per unit (0.1 mg per unit)
10 mg + 2 mL5,000 mcg/mL (5 mg/mL)50 mcg per unit (0.05 mg per unit)
10 mg + 3 mL3,333.33 mcg/mL (3.33333 mg/mL)33.33 mcg per unit (0.03333 mg per unit)
50 mg + 1 mL50,000 mcg/mL (50 mg/mL)500 mcg per unit (0.5 mg per unit)
50 mg + 2 mL25,000 mcg/mL (25 mg/mL)250 mcg per unit (0.25 mg per unit)
50 mg + 3 mL16,666.67 mcg/mL (16.66667 mg/mL)166.67 mcg per unit (0.16667 mg per unit)

Frequently asked questions

Does epitalon lengthen telomeres?

In cultured human cells it switched on telomerase and lengthened telomeres. There is no good evidence that it does this, or slows aging, in living people.

Is epitalon the same as epithalamin?

No. Epithalamin is an extract from animal pineal glands. Epitalon is a lab-made four-amino-acid peptide designed to copy its effects.

Is epitalon legal?

It is not approved anywhere for human use. In July 2026 an FDA advisory committee recommended allowing it in pharmacy compounding, but the FDA hasn't decided.

Sources

  1. Overview of Epitalon: Highly Bioactive Pineal Tetrapeptide with Promising Properties (2025), International Journal of Molecular Sciences
  2. NCPA (2026), FDA advisory committee nominates six peptides for pharmacies to compound
  3. FDA, Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks

Last updated .

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