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Research peptide

What is humanin?

Humanin explained in plain English: what it is, what the research shows, side effects, legal status and dosage, plus a calculator for syringe units. There is no validated human dose, and this page doesn't invent one. Also called HN, HNG (S14G-humanin analog).

Humanin is not approved for human use by the FDA or any other regulator. This page is educational; talk with a qualified healthcare professional before using any substance.

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Vial unit

= 5,000 mcg

mL
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–units

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Syringe, no result yetU-100, 1 mL syringe holding up to 100 units. Enter your dose.0102030405060708090100

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What is humanin?

Humanin is a small peptide of 24 amino acids made from instructions in mitochondrial DNA. It was discovered in 2001 in brain cells that survived damage like that seen in Alzheimer’s disease.

Like MOTS-c, it is called a mitochondrial-derived peptide. Lab-made humanin, and a stronger version called HNG, are sold online as research peptides.

What does humanin do?

In cells and animals, humanin protects cells from dying under stress, such as low oxygen or toxic proteins, and improves how the body handles insulin. It works through receptors on the cell surface and inside cells.

What does the research on humanin show?

Studies in worms and mice linked humanin to longer lifespan and better health in old age, and blood levels appear to fall with age in people. All treatment research is in cells and animals.

There are no human trials showing that taking humanin protects the brain, improves metabolism or slows aging.

Humanin side effects and risks

Its side effects in people are unknown. Products sold online aren’t checked for purity, strength or sterility.

Humanin is not approved for human use by the FDA or any other regulator.

How do you reconstitute Humanin?

Humanin research vials hold a freeze-dried powder that is mixed with bacteriostatic water. The calculator above turns the vial size, the water and a dose into syringe units, and the reconstitution guide explains each step.

See the dosage section below for what is known about doses, with sources.

Humanin dosage

Humanin has not been tested as a treatment in human trials, so there is no validated human dose.

There is no approved or validated human dose. This site does not repeat doses from forums, sellers or animal studies.

Medical disclaimer: this dosage information is for education only and comes from the source shown for each row. It is not medical advice and not a recommendation for you. Only a licensed prescriber who knows your health can decide whether Humanin is right for you and at what dose. Don't start, change or stop a medicine based on this page, and don't use research peptides or unapproved drugs based on trial doses.

Humanin concentration chart

The concentration of a Humanin vial depends only on its size and the water you add. Each unit on a U-100 syringe holds one hundredth of a mL.

Humanin concentration by vial size and water
Vial + waterConcentrationPer unit (U-100)
5 mg + 1 mL5,000 mcg/mL (5 mg/mL)50 mcg per unit (0.05 mg per unit)
5 mg + 2 mL2,500 mcg/mL (2.5 mg/mL)25 mcg per unit (0.025 mg per unit)
5 mg + 3 mL1,666.67 mcg/mL (1.66667 mg/mL)16.67 mcg per unit (0.01667 mg per unit)
10 mg + 1 mL10,000 mcg/mL (10 mg/mL)100 mcg per unit (0.1 mg per unit)
10 mg + 2 mL5,000 mcg/mL (5 mg/mL)50 mcg per unit (0.05 mg per unit)
10 mg + 3 mL3,333.33 mcg/mL (3.33333 mg/mL)33.33 mcg per unit (0.03333 mg per unit)

Frequently asked questions

What does humanin do?

In cells and animals it protects against cell death from stress, and it improves insulin sensitivity. Whether taking it helps people is unknown.

How is humanin related to MOTS-c?

Both are made from instructions in mitochondrial DNA, so they are called mitochondrial-derived peptides. They act differently and neither is approved.

Do humanin levels drop with age?

Studies suggest blood levels fall with age in people and animals, which is why it is studied in aging research.

Sources

  1. Yen et al. (2020), The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan, Aging
  2. Journal of Molecular Endocrinology, The emerging role of humanin in stress resistance

Last updated .

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