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Research peptide

What is kisspeptin?

Kisspeptin explained in plain English: what it is, what the research shows, side effects, legal status and dosage, plus a calculator for syringe units. Doses shown come only from the label or published trials, each with its source. Also called Kisspeptin-10, Kisspeptin-54, Metastin.

Kisspeptin is not approved for human use by the FDA or any other regulator. This page is educational; talk with a qualified healthcare professional before using any substance.

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Syringe, no result yetU-100, 1 mL syringe holding up to 100 units. Enter your dose.0102030405060708090100

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What is kisspeptin?

Kisspeptin is a natural hormone made in the brain that switches on the reproductive system. Without it, puberty doesn’t start and fertility doesn’t work normally.

Lab-made versions, mainly kisspeptin-10 and kisspeptin-54 (named for their length in amino acids), are used in research and sold online as research peptides.

What does kisspeptin do?

Kisspeptin tells the brain to release GnRH, which makes the pituitary gland release LH and FSH. Those hormones then drive testosterone in men and estrogen and ovulation in women.

It also seems to affect sexual arousal and attraction, based on brain-imaging studies in people.

What does the research on kisspeptin show?

Kisspeptin is one of the better-studied research peptides in people. In a 2014 IVF trial, a single injection of kisspeptin-54 triggered egg maturation in almost all women, and later studies tested it in women at high risk of ovarian hyperstimulation syndrome.

It has also been studied for low libido, missing periods and low testosterone. These trials were small and short, and kisspeptin isn’t an approved treatment for any of them.

Kisspeptin side effects and risks

In clinical studies, side effects were usually mild, such as flushing or headache. Used outside a study, it can disrupt the body’s own hormone balance, and repeated use may make the system less responsive.

The FDA has flagged possible immune reactions and limited safety data for kisspeptin-10, and products sold online aren’t checked for purity or strength.

Kisspeptin is not approved for human use by the FDA or any other regulator. It is used legally in registered clinical trials, but kisspeptin-10 is on the FDA’s list of compounding substances with safety concerns.

How do you reconstitute kisspeptin?

Kisspeptin comes as a powder that is mixed with bacteriostatic water. The calculator above turns the vial size, the water and a dose into syringe units, and the reconstitution guide explains each step.

See the dosage section below for what is known about doses, with sources.

Kisspeptin dosage in clinical trials

Kisspeptin is not approved. In the 2014 IVF trial, a single injection of kisspeptin-54 was dosed by body weight, in nanomoles per kilogram, to trigger egg maturation.

Doses tested in published clinical trials. They are not approved doses, and trial participants were closely monitored.

Kisspeptin doses, with sources
WhenDoseHow often
IVF trial (kisspeptin-54), single injection1.6 to 12.8 nmol/kg[1]Once
  1. Jayasena, Abbara et al. (2014), Kisspeptin-54 triggers egg maturation in IVF, J Clin Invest

Medical disclaimer: this dosage information is for education only and comes from the source shown for each row. It is not medical advice and not a recommendation for you. Only a licensed prescriber who knows your health can decide whether Kisspeptin is right for you and at what dose. Don't start, change or stop a medicine based on this page, and don't use research peptides or unapproved drugs based on trial doses.

Kisspeptin concentration chart

The concentration of a Kisspeptin vial depends only on its size and the water you add. Each unit on a U-100 syringe holds one hundredth of a mL.

Kisspeptin concentration by vial size and water
Vial + waterConcentrationPer unit (U-100)
5 mg + 1 mL5,000 mcg/mL (5 mg/mL)50 mcg per unit (0.05 mg per unit)
5 mg + 2 mL2,500 mcg/mL (2.5 mg/mL)25 mcg per unit (0.025 mg per unit)
5 mg + 3 mL1,666.67 mcg/mL (1.66667 mg/mL)16.67 mcg per unit (0.01667 mg per unit)
10 mg + 1 mL10,000 mcg/mL (10 mg/mL)100 mcg per unit (0.1 mg per unit)
10 mg + 2 mL5,000 mcg/mL (5 mg/mL)50 mcg per unit (0.05 mg per unit)
10 mg + 3 mL3,333.33 mcg/mL (3.33333 mg/mL)33.33 mcg per unit (0.03333 mg per unit)

Frequently asked questions

What does kisspeptin do?

It is the switch that starts the body's reproductive hormones. Kisspeptin tells the brain to release GnRH, which leads to LH and FSH and then testosterone, estrogen and ovulation.

Why is it called kisspeptin?

The gene that makes it, KISS1, was discovered in Hershey, Pennsylvania, and named after Hershey's Kisses chocolates.

Is kisspeptin approved?

No. It has been tested in human trials, including IVF, but it isn't approved for any use. The FDA lists kisspeptin-10 among compounding substances with safety concerns.

Sources

  1. Jayasena, Abbara et al. (2014), Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization, Journal of Clinical Investigation
  2. FDA, Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks
  3. ClinicalTrials.gov, The Use of the Hormone Kisspeptin in IVF Treatment

Last updated .

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