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What is the MGF peptide (and PEG-MGF)?

MGF explained in plain English: what it is, what the research shows, side effects, legal status and dosage, plus a calculator for syringe units. There is no validated human dose, and this page doesn't invent one. Also called Mechano growth factor, PEG-MGF, Pegylated MGF, IGF-1Ec.

MGF is not approved for human use by the FDA or any other regulator. This page is educational; talk with a qualified healthcare professional before using any substance.

Calculate
Vial unit

= 2,000 mcg

mL
Dose unit
Syringe type
Syringe size

Units to draw

–units

Enter your dose.

Syringe, no result yetU-100, 1 mL syringe holding up to 100 units. Enter your dose.0102030405060708090100

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What is the MGF peptide?

The MGF peptide (mechano growth factor) is a lab-made piece of a form of IGF-1 that muscles make when they are stretched or damaged. That form is called IGF-1Ec, and MGF copies its unique tail end.

PEG-MGF is the same peptide with polyethylene glycol (PEG) attached so it lasts longer. Both are sold online for muscle growth and recovery.

What does MGF do?

In animal and cell studies, MGF switches on muscle stem cells (satellite cells), which help repair and grow muscle after injury. Natural MGF appears briefly after exercise or damage and then fades.

What does the research on MGF show?

The evidence comes from cells and animals, and results have been mixed even there; some labs couldn’t repeat the muscle stem cell effects. There are no human trials of injected MGF or PEG-MGF.

MGF side effects and risks

Their side effects in people are unknown. Because MGF is related to IGF-1, it may affect blood sugar and tissue growth, and products sold online aren’t checked for purity or strength.

MGF and PEG-MGF are not approved for human use anywhere. Mechano growth factors are banned in sport at all times by the World Anti-Doping Agency.

How do you reconstitute MGF?

MGF research vials hold a freeze-dried powder that is mixed with bacteriostatic water. The calculator above turns the vial size, the water and a dose into syringe units, and the reconstitution guide explains each step.

See the dosage section below for what is known about doses, with sources.

MGF dosage

MGF and PEG-MGF have only been studied in cells and animals, so there is no validated human dose.

There is no approved or validated human dose. This site does not repeat doses from forums, sellers or animal studies.

Medical disclaimer: this dosage information is for education only and comes from the source shown for each row. It is not medical advice and not a recommendation for you. Only a licensed prescriber who knows your health can decide whether MGF is right for you and at what dose. Don't start, change or stop a medicine based on this page, and don't use research peptides or unapproved drugs based on trial doses.

MGF concentration chart

The concentration of a MGF vial depends only on its size and the water you add. Each unit on a U-100 syringe holds one hundredth of a mL.

MGF concentration by vial size and water
Vial + waterConcentrationPer unit (U-100)
2 mg + 1 mL2,000 mcg/mL (2 mg/mL)20 mcg per unit (0.02 mg per unit)
2 mg + 2 mL1,000 mcg/mL (1 mg/mL)10 mcg per unit (0.01 mg per unit)
2 mg + 3 mL666.67 mcg/mL (0.66667 mg/mL)6.67 mcg per unit (0.00667 mg per unit)
5 mg + 1 mL5,000 mcg/mL (5 mg/mL)50 mcg per unit (0.05 mg per unit)
5 mg + 2 mL2,500 mcg/mL (2.5 mg/mL)25 mcg per unit (0.025 mg per unit)
5 mg + 3 mL1,666.67 mcg/mL (1.66667 mg/mL)16.67 mcg per unit (0.01667 mg per unit)

Frequently asked questions

What is the difference between MGF and PEG-MGF?

PEG-MGF is MGF with polyethylene glycol (PEG) attached, which makes it last much longer in the body. Neither has been tested in human trials.

Does MGF build muscle?

In animal and cell studies it helped muscle repair. Whether injected MGF builds muscle in people is unknown.

Is MGF banned in sport?

Yes. Mechano growth factors are prohibited at all times by the World Anti-Doping Agency.

Sources

  1. Wikipedia, Mechano growth factor (with cited studies)
  2. World Anti-Doping Agency, The Prohibited List

Last updated .

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